منابع مشابه
A hybrid mammalian cell cycle model
Hybrid modeling provides an effective solution to cope with multiple time scales dynamics in systems biology. Among the applications of this method, one of the most important is the cell cycle regulation. The machinery of the cell cycle, leading to cell division and proliferation, combines slow growth, spatio-temporal re-organisation of the cell, and rapid changes of regulatory proteins concent...
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Dysregulation of the mammalian target of rapamycin (mTOR) kinase pathway is centrally involved in a wide variety of cancers and human genetic diseases. In mammalian cells, mTOR is part of two different kinase complexes: mTORC1 composed of mTOR, raptor and mLST8, and mTORC2 containing mTOR, rictor, sin1 and mLST8. Whereas, mTORC1 is known to be a pivotal regulator of cell size and cell cycle con...
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An analysis of different classes of forced or batch synchronization methods reveals why these methods, in theory, do not produce synchronized cultures. Cells may be aligned for a particular property after specific treatments, but these aligned cells do not correspond to any particular cell age during the normal cell cycle. The experimental methods analyzed are those that arrest CMLS, Cell. Mol....
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The cellular division cycle is an essential process to ensure healthy tissue homeostasis, which can, due to its periodicity, be interpreted as a biological oscillator. This work focuses on identifying the main mechanisms underlying cell cycle rhythms in mammals and propose a mathematical model to describe them. The model is based on post-translational modifications of cyclin Bcdk1, also called ...
متن کاملA Computational Model of Mammalian Cell Cycle Using Petri Nets
The mammalian cell cycle is regulated by Cyclin-dependent kinases (Cdks) whose activity is strictly controlled by the physical association with regulatory subunits known as Cyclins and by the phosphorylation and dephosphorylation of catalytic subunits. In higher eukaryotes, Cdk2-cyclin A and Cdc2-cyclin B (MPF) are needed for the maintenance and progression of the S phase and mitosis, respectiv...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1993
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.42.497